Multiple genetic variants have been identified that are associated with cardiovascular disease. Genovate offers a comprehensive DNA Cardiovascular Health Test that analyzes variants in 27 genes (listed below), which each affect different aspects of cardiovascular health.
Triglycerides - main form of fat (or lipid) found in the body:
- MLXIPL
- ANGPTL3
- NCAN
- LPL
- TRIB1
- NOS3
- GALNT2
LDL cholesterol - considered “bad” cholesterol:
- APOB
- SORT1
- LDLR
- PCSK9
- SUGP1
- NCAN
- TRIB1
- HMGCR
- HNF1A
HDL cholesterol - considered "good" cholesterol):
- CETP
- LCAT
- LPL
- ANGPTL4
- GALNT2
- LIPG
- MMAB
- HNF4A
Other aspects of cardiovascular health, including lipoprotein(a) levels, lipid metabolism, cell proliferation, and processing of unsaturated fats, are affected by variants in the following genes/regions:
- LPA
- APOA5/A4/C3/A1
- LIPC
- FADS1
- 9p21
- GCKR